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Research Associate/Fellow (Mass Spectrometry Analysis of Organic Surfaces and Interfaces) (Fixed term)
Pharmacy
| Location: |
University Park |
| Salary: |
£29,762 to £36,333
per annum (pro rata if applicable) depending on skills and experience (minimum £33348 with relevant PhD).
|
| Closing Date: |
Wednesday 07 June 2023 |
| Interview Date: |
To be confirmed
|
| Reference: |
SCI595122X1 |
We are currently seeking postdoctoral scientists to join an EPSRC funded project that will design bio-instructive materials for translation ready medical devices.
A novel class of polymers developed in our labs show great promise in reducing infections and controlling host response in the clinic. We recently added the use of micro topography to provide a synergistic stimulus to tackle infections and found an improvement in the host immune response. This control of host response is applicable to achieving better implant integration and wound healing. These findings are being developed in this project to improve outcomes for medical devices in the clinic.
The reason bacteria do not form adherent biofilms on our novel polymer surfaces is not well understood, so in this EPSRC funded project we will use combinatorial material libraries in ChemoTopo Chips to screen performance. We will develop models across a range of surfaces correlating surface chemistry, topography and bio-interfacial composition with bacterial, immune and stromal cell responses. These models will be used to design optimal materials for use as implanted meshes and external chromic wound care products for the post antibiotic era.
The project includes computational modellers and experimentalists in the fields of polymer synthesis, 3D printing, surface chemical analysis, cellular immunology, bacteriology, proteomics and metabolomics. The successful candidate will be responsible for the mass spectrometry aspects of the project including Liquid extraction surface analysis (LESA), matrix-assisted laser desorption/ionisation (MALDI), 3DOrbiSIMS and liquid-chromatography (LC-MS) experiments. Experience with mass spectrometry analysis, data acquisition and interpretation is essential. Experience with surface-based mass spectrometry approaches or metabolomics/lipidomics, mass spectrometry data interpretation or in vitro models are highly desirable.
Candidates must have a PhD in preparation or awarded in the area of physical or biological sciences. This is a collaborative project between the School of Pharmacy, The School of Computer Science, Physics and Astronomy, the School of Life Sciences and the Faculty of Engineering.
This full-time (36.25 hour) post is offered on fixed-term contract for 36 months; starting no later than February 2024. Job share arrangements may be considered.
We pride ourselves on the collegial and supportive culture created by our staff for our staff and students. We are dedicated to providing an environment which enables our staff to thrive and achieve their potential. Our commitment to Equality and Diversity has been recognised in the awards of Athena Swan Awards to the collaborating schools and faculties.
Informal enquiries can be directed to rian.griffiths@notingham.ac.uk and applications can be made through the University of Nottingham’s Vacancy Manager system.
Further details:
Our University is a supportive, inclusive, caring and positive community. We warmly welcome those of different cultures, ethnicities and beliefs – indeed this very diversity is vital to our success, it is fundamental to our values and enriches life on campus. We welcome applications from UK, Europe and from across the globe. For more information on the support we offer our international colleagues, see our Moving to Nottingham pages.
Please note that applicants for this post will be considered on an equal basis, subject to the relevant permission to work in the UK as defined by the requirements set out by UK Visas & Immigration. Please visit: https://www.gov.uk/government/organisations/uk-visas-and-immigration for more information.
For successful international applicants, we provide financial support for your visa and the immigration health surcharge, plus an interest-free loan to help cover the cost of immigration-related expenses for any dependents accompanying you to the UK. For more information please see the our webpage on Financial support for visas and the immigration health surcharge.