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Research Fellow / Research Associate (Fixed term)

School of Medicine, Translational Medical Sciences, Cancer and Stem Cells

Location:  University Park
Salary:  £28,762 to £43,414 per annum, depending on skills and experience (minimum £32348 with relevant PhD). Salary progression beyond this scale is subject to performance
Closing Date:  Friday 17 February 2023
Reference:  MED610022

The University is seeking to appoint a Research Fellow to have specific responsibility for research, developing research objectives and proposals for a research project in stem cell biology. You will manage, plan and conduct own research activity using recognised approaches, methodologies and techniques within the research area and resolve problems in meeting research objectives and deadlines in collaboration with others. You will need a PhD or equivalent in relevant subject area or the equivalent in professional qualifications and experience in research area or be near to completion of a PhD. 

The central research question is to ask whether novel genetic loci and pathways are beneficial or detrimental to heart function, and ultimately heart failure. You will be expected to plan and conduct work using approaches or methodologies and techniques appropriate to the type of research and will be responsible for writing up your work for publication. The specific objectives we will address will be to:

1) Create human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) cultures in which novel RNAs are knocked out with CRISPR or upregulated by forced overexpression 

2) Use high throughput/content and/or automated approaches to ask what impact modulation of RNAs has on gene expression, structure & function of hiPSC-CMs 

3) Use a systems biology approach to integrate data on the transcriptome and proteome to unveil new mechanistic insight by identifying target pathways 

You will need the ability to build relationships and collaborate with others, both internally and externally. The project is joint between the University of Nottingham, King’s College London and the Cardiovascular Research Institute (Singapore). You will work closely with staff at each location to prepare data, present the work (including summaries, conclusions and next steps), exchange resources and facilitate tech transfer in a two-way manner. This may involve travel and working between sites. 

You will join an established team, led by Prof. Chris Denning, whose main areas of research interest include using human pluripotent stem cells to explore heart function, repair and regeneration with regards drug-gene interactions, disease modelling and cell therapy. The role includes contribution to efficient running of labs, including adherence to processes for Health & Safety. You are also expected to make a contribution to teaching that is in balance with wider contributions to research and other activities (not more than 10% of time).

You will identify opportunities and assist in writing bids for research grant applications, prepare proposals and applications to both external and/or internal bodies for funding, contractual or accreditation purposes.

You will have the opportunity to identify areas for research, develop research methods and extend your research portfolio.

The post is fixed term until 16 January 2025. Hours are full time (36.25 hours per week). 

Informal enquiries may be addressed to Chris Denning on email Please note that applications sent directly to this email address will not be accepted.

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