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Research Associate/Fellow in protein production, target validation and in vitro assay development (Fixed term)

Pharmacy

Location:  University Park
Salary:  £28,762 to £36,386 per annum (pro rata if applicable) depending on skills and experience (minimum £32348 with relevant PhD).
Closing Date:  Monday 12 December 2022
Reference:  SCI525422

We are seeking a Research Associate/Fellow to join a project funded by the beLAB1407 initiative that is a partnership between a university consortium, Bristol Meyer Squibb and Evotec, created to transform leading science into novel therapeutics and treatments. The project aim is to support the early stages of a drug discovery campaign by generating recombinant protein and developing FRET/FP based assays for high-through-put small molecule screening, as well as conducting target validation studies using a panel of cancer cell lines. 

The role holder will be involved in the construct design, molecular cloning, protein expression/purification and development of assays for the identification of protein-protein interaction inhibitors and conduct viability assays using siRNA and cell penetrating peptides for target validation. The successful candidate will join a multidisciplinary research team at the School of Pharmacy (Ingrid Dreveny, Lodewijk Dekker) and School of Medicine (Srinivasan Madhusudan) and work closely with our industrial partners to drive drug discovery efforts to develop novel anti-cancer therapeutics.

Candidates should have or be close to completion of a PhD in a discipline relevant to the project such as biochemistry or cell biology. Past experience of recombinant protein expression/purification and mammalian cell culture and preferably the use of FRET or FP assays is essential. A knowledge of cell viability assays and/or cell functional assays would be desirable. The candidate will be required to undertake research and day-to-day management of this research project, requiring a high degree of time management and organisational skills, competence and precision in conducting the experiments and data analysis. An aptitude for critical thinking, industry standard record keeping and a flexible approach to collaborative research is vital.

This full-time post (36.25 hours per week) will be offered on a fixed-term contract for 13 months. However, please note if start date is delayed there is a fixed funding end date of 29th February 2024. Job share arrangements may be considered.

Our university has always been a supportive, inclusive, caring and positive community. We warmly welcome those of different cultures, ethnicities and beliefs – indeed this very diversity is vital to our success, it is fundamental to our values and enriches life on campus. We welcome applications from UK, Europe and from across the globe. For more information on the support, we offer our international colleagues visit www.nottingham.ac.uk/jobs/applyingfromoverseas/index2.aspx

We pride ourselves on the collegial and supportive culture created by our staff. We are dedicated to creating an environment which enables both our staff to thrive and achieve their potential. Our commitment to Equality and Diversity has been recognised in the awarding of an Athena SWAN Silver Award.

Informal enquiries can be addressed to Dr Ingrid Dreveny (ingrid.dreveny@nottingham.ac.uk). Please note that applications sent directly to this email address will not be accepted.

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Our University is a supportive, inclusive, caring and positive community. We warmly welcome those of different cultures, ethnicities and beliefs – indeed this very diversity is vital to our success, it is fundamental to our values and enriches life on campus. We welcome applications from UK, Europe and from across the globe. For more information on the support we offer our international colleagues, see our Moving to Nottingham pages.

For successful international applicants, we provide financial support for your visa and the immigration health surcharge, plus an interest-free loan to help cover the cost of immigration-related expenses for any dependants accompanying you to the UK. For more information please see the our webpage on Financial support for visas and the immigration health surcharge.

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