Research Associate/Fellow: Formulations for RNA-Therapeutics Delivery (Fixed term)
We are currently seeking a postdoctoral scientist with skills in Formulations for RNA-Therapeutics Delivery to join a multi-disciplinary team working on an industry-academic collaborative project “Supramolecular RNA therapeutics (SMRTs) - developing tunable formulations with scale-independent manufacture” funded by InnovateUK under the “Innovative technologies for intracellular drug delivery” programme. The objective of the Supramolecular RNA therapeutics project is to develop manufacturable RNA therapies for Triple Negative Breast Cancers. The project is led at Nottingham by Professors Cameron Alexander and Snow Stolnik in Pharmacy, and Professors Alan McIntyre, Poulam Patel and Srinivasan Madhusudan in Medicine, and will investigate novel formulations for RNA therapeutics which can be personalised for Triple Negative Breast Cancer patients.
This post involves collaborations with the Cambridge spin-out companies Aqdot and Centillion, and will be focused on the design and synthesis of polymers that can generate “supramolecular polyplexes” which enhance RNA therapeutic efficacy while reducing toxicity of comparable non-supramolecular systems. The vision is to provide safe, low-cost formulations which can be manufactured rapidly and locally.
The work will involve direct interactions with the partner research groups at Aqdot and Centillion, with visits to their sites in Cambridge as necessary during the project.
The post will be based across labs in the Boots Science Building and BDI. Candidates must have a PhD submitted or awarded in Chemistry or related discipline and a track record in polymer synthesis. Experience in physicochemical characterisation techniques used in supramolecular and colloid chemistry is desirable.
Hours of work are full time (36.25 hours per week). Job share arrangements would be considered. The post is offered on a fixed term contract until 31st July 2025.
Requests for secondment from internal candidates may be considered on the basis that prior agreement has been sought from both your current line manager and the manager of your substantive post, if you are already undertaking a secondment role.
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Informal enquiries may be addressed to Professors Cameron Alexander (cameron.alexander@nottingham.ac.uk) and Snow Stolnik (snow.stolnik@nottingham.ac.uk) at UoN. Please note that applications sent directly to these email addresses will not be accepted.
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